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KMID : 1039420210550010068
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Journal of Pathology and Translational Medicine
2021 Volume.55 No. 1 p.68 ~ p.74
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A case of cribriform carcinoma of the skin: a newly described rare condition
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Lee Hyun
Won Chong-Hyun
Park Chan-Sik
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Abstract
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Primary cribriform carcinoma of the skin is an indolent, rare, adnexal tumor. Although its malignant potential remains uncertain, no recurrence or metastasis has been reported. A 33-year-old man presented with a solitary, erythematous, subcutaneous nodule on the right knee. The clinical impression was epidermal cyst, and the resected tumor demonstrated a well-circumscribed mass in the dermis and subcutis. The tumor was composed of two regions: a solid component and a cribriform component. The solid component (90%) showed multiple solid nests of epithelial cells. Individual cells had large, oval-to-round, hyperchromatic, pleomorphic nuclei with a nuclear groove. The cribriform component (10%) showed similar neoplastic cells with many prominent lumina. Some lumina had an eosinophilic substance that exhibited a positive periodic acid-Schiff reaction. No recurrence or metastasis was observed within a follow-up period of eight months after excision. In conclusion, we report the first case of primary cribriform carcinoma of the skin in Korea.
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KEYWORD
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Cribriform carcinoma, Apocrine tumor, Skin tumor
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